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Atherosclerosis Is The Major Cause Of The Cardiovascular Disease (CVD), The Predominant Cause Of Death Worldwide. Several Previous Studies Demonstrated That Dyslipidemia, Oxidation, And Inflammation Related To The Pathogenesis Of Atherosclerosis. Previous Clinical Studies Revealed That These Of White Kwao Krua As A Hormone Replacement Therapy Has Beneficial Effects On The Lipid Profile Of Menopause Women. In This Present Study, Weutilized The Hypercholesterolemia Rabbit Model To Demonstrate The Effect Of White Kwao Krua On The Daily Intake Of a High-fat Diet.We Inducedhypercholesterolemia In Rabbits By Feeding With High-fat Diet (1% Cholesterol-containing Diet). The Animals Were Maintained for 12 Weeks For The experimentation. The White Kwao Krua Supplement Was Administered 100 Mg/Kg/Day, And The Effects Were Monitored Comparing With Statins Andturmeric.
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Blood Was Collected Periodically To Monitor The Plasma Cholesterol Level And The Oxidative Susceptibility Of Isolated Ldl-cholesterol. At the end Of The Experiment, The Aorta Was Collected From The Animal And Performed Endothelial-dependent Relaxation And Endothelial-independent Relaxation Assays. The Accumulation Of Ldl Transforms Into Oxidized-ldl (Oxldl) And Constitutes The Hallmark Of The Disease. The Presence Of Oxldl Not Only Produces Self-reactive Oxygen Species (Ros) But Also Activates Endothelial Cells To Release More Ros And Pro-inflammatory Cytokines.2 This Increases The Leukocyte Migration, Subendothelial Space Retention,3 Leukocyte Adhesion To The Vascular Endothelial Cells,4 And Even Synergizes The Effect Of Air-pollutant-induced Vascular Inflammation. White Kwao Krua Tablets In Pakistan And Dubai
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